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VIN-III: severe dysplasia or carcinoma in situ How do each of the preinvasive lesions typically present VIN-I and VIN-II present most commonly with itching, chronic irritation, and development of a palpable lesion The lesion typically appears as localized, isolated, raised, whitish areas found most commonly along the posterior vulva and perineal body Perineal pain and dysuria can also be presenting symptoms VIN-III typically presents with intractable itching and irritation along with the gross lesion(s) described above Occasionally, the vuvlar involvement is extensive Complete excision Early cases with limited involvement can be treated with local excision, cryocautery, electrodesiccation, or laser ablation VIN-III is treated with wide local excision with/without laser ablation Vulvar cancer is the fourth most common gynecologic cancer that affects almost 4000 women in the United States annually Typically, postmenopausal women, usually around 65 years of age Infection with certain types of HPV history of cervical cancer Immunocompromise; northern European ancestry Cigarette smoking; diabetes Vulvar dystrophy; obesity Vulvar intraepithelial neoplasia; hypertension How is the diagnosis of vulvar cancer made Careful history-taking and inspection are essential Inspection must include all of the vulvar skin, peri-anal skin, cervix, and vagina A biopsy of each lesion leads to a definitive diagnosis as gross appearance is often inconsistent with the underlying cellular morphology If there is no obvious lesion, colposcopy may be

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used Also, the skin can be washed with a dilute acetic acid solution to accentuate any lesions or aberrant vascular patterns What other test should be ordered after biopsy A synchronous secondary malignancy is found in over 20% of patients with vulvar cancer and so screenings for a secondary malignancy as well as for metastasis should be done Screenings may include: CXR; IVP; LFTs; renal function tests; CT scan If the lesion is located near the anus then a barium enema is warranted and if the lesion is located near the urethra then cystoscopy is warranted What is the differential diagnosis of a suspected vulvar cancer Epidermal inclusion cysts; seborrheic keratoses Lentigo condyloma acuminata Bartholin gland disorders; lichen sclerosus Acrochordons; hidradenomas What are the types of vulvar cancer Over 90% of vulvar cancers are primary cancers Types of primary vulvar cancers include: squamous cell carcinomas (90%); melanomas (5%); Bartholin s gland carcinomas; basal cell carcinomas; sarcomas; lymphomas; endodermal sinus tumors Metastasizing cancers to the vulva include cervical, endometrial, renal, and urethral cancers

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What are the signs/symptoms of squamous cell vulvar cancer Itching, burning, irritation, and/or the development of a palpable lesion (plaque, ulcer, or mass) usually on the labia majora Bleeding, ulceration, abnormal discharge, dysuria, or an enlarged groin lymph node are usually associated with more advanced disease

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